Deterministic lateral displacement (DLD) is an efficient approach to separate small spherical particles or cells using an array of staggered obstacles, such as rectangular or cylindrical posts. Particles or cells that are smaller than the post spacing remain in their lanes, while large particles are deflected to neighboring lanes. This glass microfluidic chips are designed for particle or cell separation in a continuous flow. The fluidic access inlet and outlet ports can be bonded with NanoPort assemblies or can be inserted with stainless steel tubes.

Key Features

Optical transparency and high visibility
Excellent chemical compatibility
Quick and easy to connect/disconnect
Operating pressure up to 100 psi
Etched channel surface roughness (Ra): 5-10 nm
Glass-glass thermal fusion bonding
Flexible for chip post-processing, such as hydrophobic or fluorophilic coating

Typical Applications

Separations of micrometer/sub-micrometer particles or cells, such as circulating tumor cells (CTC) or bacteria
Coupled with external forces to separate particles on the basis of deformability or dielectric properties of particles, such as red blood cells (RBCs) and DNAs

Obstacle Size	50 µm diameter cylindrical post array
Obstacle Distance	170 µm (center-to-center)
Chip Overall Dimensions	50.0 mm x 80.0 mm x 3.0 mm
Chip Thickness	Top layer: 1.5 mm; Bottom layer: 1.5 mm
Channel Surface Roughness (Ra)	5-10 nm
Surface Wettability	Hydrophilic
Maximum Operating Pressure	100 psi
Material	Borofloat 33